Central nervous system (CNS) manifestations can follow both primary infection or reactivation by VZV and occur without concomitant skin rash in up to a third to half of patients, referred to as "zoster sine herpete". Varicella-zoster virus (VZV) is an α-herpesvirus with the ability to establish latency in dorsal-root ganglia or cranial-nerve ganglia. Sun In Hong, 1 Taeeun Kim, 2 Jiwon Jung, 3 Se Yoon Park, 4 Yong Pil Chong, 5 Sang-Oh Lee, 5 Sang-Ho Choi, 5 Yang Soo Kim, 5 Jun Hee Woo, 5 Sang-Ahm Lee, 6ġDivision of Infectious Diseases, Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon, Korea.ĢDivision of Infectious Diseases, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.ģDivision of Infectious Diseases, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.ĤDivision of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.ĥDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ĦDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Tuberculous Meningitis-Mimicking Varicella-Zoster Meningitis English.Ĭopyright © 2017 by The Korean Society of Infectious Diseases and Korean Society for Chemotherapy Reddy PV, Shetageri V, Kumar K R, Anuroop L, Gopalakrisnan GAffective Psychosis: A Rare Presentation of Tubercular Meningitis in a Tertiary Care Hospital.JCR 2017 7:408-410.Infect Chemother. Reddy PV, Shetageri V, Kumar K R, Anuroop L, Gopalakrisnan GAffective Psychosis: A Rare Presentation of Tubercular Meningitis in a Tertiary Care Hospital.JCR 2017 7:408-410 Rapid diagnosis of tuberculous meningitis by polymerase chain reaction. Tuberculous meningitis- neurological aspects of tropical disease.
Another case report from a developing country reported inability to speak, altered behavior which was diagnosed as TBM at a later stage and patient succumbed to his illness.
#Tbm manifestation journal series
A case series about unusual presentations of tubercular meningitis had one of the cases presenting as paranoid psychosis. Another case where in mood disturbances in the form of depressive symptoms, cognitive difficulties and hyponatremia were presenting features of tubercular meningitis. One of the cases is of anterior callosal and frontal tuberculoma presenting with chronic psychosis and recent onset catatonia. Our literature review showed few case reports of CNS tuberculosis presenting as psychiatric disorders. Thus this case would be a rare report of such a classical presentation.
#Tbm manifestation journal full
Literature review shows several cases of tubercular meningitis presenting with behavioral and cognitive symptoms but cases presenting as full psychiatric syndrome are very few which have been mentioned later in the text and presentation as mood disorder is even sparse. Tuberculosis may manifest with atypical clinical manifestations and delayed diagnosis may give rise to unexpected grave outcomes. The usual mental disturbances associated are apathy, irritability, and insidious changes in personality as among the chief characteristics of the early stages of the illness. Tuberculosis of the nervous system can involve the meninges, brain, spinal cord, cranial and peripheral nerves, ears, and eyes.
Al-though tuberculous meningitis (TBM) is the least commonly observed form of extra-pulmonary TB (5-15%) but is the most severe form in terms of mortality and morbidity. Tuberculosis (TB) is a disease which has been affecting humanity since archaic ages.
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